“Trough” Also referred to as “level” should always be before a dose (trough) even if provider does not specify Aminoglycosides: Amikacin Within 30 minutes before 3rd or 4th dose (pediatrics: 3rd dose) 2-3 doses Trough: < 8 mg/L Aminoglycoside special considerations: Refer to UCSF Infectious Disease Management Program (IDMP)

This study aimed to identify the tacrolimus trough levels (TTL)-mean, TTL-standard deviation (SD), and TTL- coefficient of variation (CV) as well as factors affecting these values over a 2-year period in clinically stable patients > 5 years after kidney transplantation (KT).

Little is known regarding optimal tacrolimus (TAC) trough levels after 1 year post-transplant in stable kidney transplant recipients (KTRs) who have not experienced renal or cardiovascular outcomes. This study aimed to investigate the effect of ...

We found that a long-term tacrolimus blood trough level of 4.6–10.2 ng/mL in adult LT recipients is associated with a lower mortality rate. In patients with a serum creatinine > 1.3 mg/dL, a mean tacrolimus blood trough level of 4.4–6.3 ng/mL is associated with a lower mortality rate.

Dec 7, 2021 · This study aimed to identify the tacrolimus trough levels (TTL)-mean, TTL-standard deviation (SD), and TTL- coefficient of variation (CV) as well as factors affecting these values over a 2-year period in clinically stable patients > 5 years after kidney transplantation (KT).

May 8, 2023 · Monitoring and maintaining an appropriate and stable tacrolimus (Tac) trough level in the early post transplantation period is essential to avoid AR. Our study investigated the relationship between AR with Tac C 0 and TTR in the first month following transplantation.

Jan 30, 2025 · Clinical studies have shown that patients administered 0.07 mg/kg Prograf® obtain an optimal response to the drug at the following trough levels: • Trough (immediately following transplant): 15.0 ng/mL • Trough (steady-state, two weeks or more after transplant): 3.0−8.0 ng/mL. 5.0–20.0 ng/mL

Mar 29, 2023 · We demonstrated that patients requiring a relatively high Tac dose to attain therapeutic C0 levels have higher drug exposure and could therefore potentially be overdosed.

In clinical practice, in the early post-transplant period, whole blood trough levels are generally between 5-20ng/mL for liver transplant recipients and 10-20ng/ml for kidney and heart transplant patients.

Aug 8, 2023 · High tacrolimus trough level variability is associated with a higher risk of adverse effects. In practice, the initial dosing and sampling time of tacrolimus levels is not standardized, which may result in resource wastage, frequent blood sampling, and a longer time to achieve therapeutic levels.