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We report an extensive in-silico investigation of phytochemicals that may serve as progesterone receptor (PR) modulators for contraception. By employing ADMET profiling, structure-activity ...

A major study of around 260,000 women shows that taking the progesterone-only contraceptive pill can increase asthma attacks in some women. The research, published in ERJ Open Research ...

Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior. Mount Sinai researchers ...

Preclinical data have shown that cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors can inhibit tumour growth and act synergistically with oestrogen receptor antagonists to overcome endocrine therapy ...

Mounting evidence has shown a role for TAM (Tyro3, AXL, MerTK) family of tyrosine kinase receptors in PDAC initiation and progression. This review aims to describe the impact of TAM receptors on the ...

Get Instant Summarized Text (Gist) Both activation (agonism) and blockade (antagonism) of the GIP receptor reduce body weight and food intake, but through distinct brain mechanisms. GIPR agonists ...