The ASO for myotonic dystrophy type 1 was well tolerated and improved splicing and function in a study presented at ASGCT.

QurAlis' FlexASO® platform was developed to generate splice-switching ASOs with improved potency, increased therapeutic index and improved bio-distribution. This bespoke platform has the potential to ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology.

CircRNAs are unique RNA molecules formed through a back-splicing mechanism that connects the 5' and 3' ends of precursor mRNA ...

Cancer immunotherapy represents a transformative approach in oncology, especially for treating cancers thought to be incurable. However, a significant ...

An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

PTC Therapeutics Inc. CEO Matthew Klein said the firm “achieved all we set out to [achieve] in phase II” with PTC-518 in ...

Moderna is currently in the very early stages of testing a bird flu vaccine using the same mRNA technology that allowed for rapid development and rollout of COVID-19 vaccines. The funds from the U.S.

Previous studies have reported that RBPs like LSM2 are involved in the regulation of mRNA stability, splicing, and translation, all of which are crucial for tumour progression. LSM2 has been shown to ...