Lawmakers in Iowa, Idaho, Texas, and Kentucky have introduced bills that would ban or restrict vaccines that use messenger ...

The ASO for myotonic dystrophy type 1 was well tolerated and improved splicing and function in a study presented at ASGCT.

QurAlis' FlexASO® platform was developed to generate splice-switching ASOs with improved potency, increased therapeutic index and improved bio-distribution. This bespoke platform has the potential to ...

CircRNAs are unique RNA molecules formed through a back-splicing mechanism that connects the 5' and 3' ends of precursor mRNA. Previously considered splicing errors, circRNAs are now recognized for ...

CircRNAs are unique RNA molecules formed through a back-splicing mechanism that connects the 5' and 3' ends of precursor mRNA. Previously considered splicing errors, circRNAs are now recognized for ...

The interaction between circular RNA (circRNA) and RNA-binding protein (RBP). The approaches to RNA therapy targeting the circular RNA (cir ...

6 The process of pre-mRNA splicing removes introns and stitches together exons to create mature mRNA. Ten percent of all disease-causing single-point mutations in humans result in splicing defects ...

While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which is subsequently disassembled and made available for a new round of splicing. Credit: Paulina Fischer ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

MIT biologists have discovered that a family of proteins known as Luc7 (shown in blue) is necessary for the accurate splicing of certain messenger RNA molecules. Credit: MIT RNA splicing is crucial ...