This image highlights two alternatives for the ribosome to be recruited to an mRNA that is still being synthesized by RNA polymerase (RNAP). RNAP (left, red) can directly deliver the mRNA to the ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called mRNA. Then, another molecule called a ribosome reads the mRNA, translating it ...

Translation Begins After the Assembly of a Complex Structure The translation of mRNA begins with the formation of a complex on the mRNA (Figure 4). First, three initiation factor proteins (known ...

Polish researchers described a new mechanism that improves the efficiency of mRNA-based therapies. From left: Prof. Andrzej Dziembowski (IIMCB and Faculty of Biology UW), Dr. Paweł S. Krawczyk (IIMCB) ...

RNA is similar to DNA but contains uracil instead of thymine (T) and has a single-stranded structure. Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases ...

To answer it, he and his colleagues first used various staining techniques to establish that both RNA-binding proteins and mRNA are colocalized with mitochondria ... throughout the cytoplasm, forming ...

“These [changes] can define the half-life of the mRNA,” Šiurkus notes. Alternatively, researchers can also modify the chemical structure of the mRNA cap found at the molecule’s 5’ en ...