Because of this flexibility, the 30 to 40 tRNAs present in a cell can "read" all 61 codons in mRNA. The opposite end of the folded structure, which is the 3' end of the tRNA, binds to its ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

However, in the half-century since the structure of DNA was first elaborated ... Generally, those RNA molecules that do not take the form of mRNA are referred to as noncoding, because they ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

Abe's team overcame this hurdle by introducing a cap structure into the circular mRNA itself. This internal cap structure triggers translation initiation, bypassing the need for IRES sequences ...

These molecules cluster around mitochondria throughout the cytoplasm, forming a structure the team named the mitochondria ... which had been previously associated with oocyte maturation and mRNA ...

Previous methods relied on long internal ribosome entry sites (IRES) for introducing the mRNA, which were difficult to optimize and often inefficient. Abe's team overcame this hurdle by introducing a ...