Cancer immunotherapy represents a transformative approach in oncology, especially for treating cancers thought to be incurable. However, a significant ...

An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators.

“We’re excited to share these enzymes with the genome editing community and to get feedback on their performance as nucleases, base editors, and as other genome editing modalities,” said ...

The team was the first in the world to describe the crucial role of the enzyme TENT5A in extending the aforementioned poly(A) tails of therapeutic mRNA molecules. "Until now, it was assumed that ...

mRNA is synthesized by the enzyme RNA polymerase ... is also exploring its roles in the regulation of alternative splicing, the regulation of mRNA levels, and the modification of N4-acetylcytidine ...

Using a fluorescent enzyme detection kit ... in contrast to the mRNA group (Figure 3C). These results demonstrate that the ability of circRNA constructed from the IIC self-splicing ribozyme to express ...

Effective treatments for ARVC are lacking. Whereas mRNA-based therapies have shown efficacy in humans, their therapeutic potential for inherited cardiomyopathies remains unclear. A novel insertion ...

O-GlcNAcylation in humans is mediated by a single essential enzyme, O-GlcNAc transferase (OGT ... these data indicate a role for SFSWAP as a global negative regulator of pre-mRNA splicing and positive ...

NEW YORK – The US Food and Drug Administration has cleared CureVac to begin a Phase I trial of its mRNA-based precision immunotherapy CVHNLC in patients with squamous non-small cell lung cancer, the ...