mRNA splicing is a fundamental part of the ... a process facilitated by splicing enzymes. In the new study, the Caltech ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

Researchers from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) have described a new mechanism ...

RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5 ... and stress response pathways involving the repair of tRNA breaks (during tRNA splicing) and mRNA breaks (during the unfolded protein ...

Splicing of pre-mRNA requires both high fidelity and enormous sequence flexibility, inevitably resulting in aberrant, stalled complexes that must be discarded. A study now describes cryo-EM ...

The resulting primary transcript, known as pre-mRNA in eukaryotes ... Other ribozymes include self-splicing introns and the RNA component of the enzyme telomerase. Non-coding RNA molecules, such as ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

The role of gut microbiome and inflammation in endometriosis. Endometriosis, which causes pain in the pelvis and lower abdomen and can lead to infertility, afflicts 1 in 10 women in reproductive age.