This week, mRNA vaccines are set to face intense scrutiny from critics in Congress. Here's an explainer of how we know they ...

In T24 human bladder carcinoma cells, these EGSs, but not control sequences, were highly effective in downregulating PKC-α protein and mRNA expression. Furthermore, the downregulation is ...

An artificial intelligence (AI) tool that optimizes the gene sequences found in mRNA vaccines could help to create jabs with greater potency and stability that could be deployed across the globe.

mRNA vaccines work by using synthetic mRNA sequences that instruct the body’s cells to produce specific antigens, typically proteins from a virus. Once injected, these mRNA molecules enter the ...

In nucleoside-modified mRNA vaccines, modifications in the mRNA sequence enable the mRNA to remain in the body longer and to induce protein synthesis more effectively. Lipid nanoparticle (LNP ...

This is a potentially useful strategy for vaccine development because multiple mRNA sequences can code for the same protein—and each crumples up in a different way. So if scientists can identify ...

The DNA is basically a book of recipes. Each recipe tells the cells in our bodies how to make specific proteins by combining ...

causing changes in gene expression without changing the DNA sequence itself. Thus, vaccination with mRNA vaccines could lead to an enhanced immune response to future encounters with pathogens ...

mRNA therapeutics are complex to design and manufacture. From mRNA sequence engineering to fill-and-finish, mRNA therapeutic development requires precise, consistent, and exacting quality analysis.

Then, they attached this SP-encoding bit of mRNA to four different mRNA sequences that produced certain proteins: mCherry, a fluorescent protein that provides a visual cue on whether it was ...