m6A is a chemical modification found on mRNA molecules. It regulates various cellular processes, including mRNA stability and degradation, and plays a role in controlling protein synthesis. The role ...

They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

Figure 3. Drosophila m6A pathway. (A) m6A writers and readers. (B) Mapping of m6A modifications (miCLIP track) relative to mRNA-seq identifies extensive modification in the intronic regions (CIMS, ...

More information: Xin-Hui Chen et al, Regulations of m6A and other RNA modifications and their roles in cancer, Frontiers of Medicine (2024). DOI: 10.1007/s11684-024-1064-8 ...

The team discovered that translation promotes mRNA degradation—a finding that may help advance the development of RNA-based drugs. The balance between translation and mRNA decay is essential for ...

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators.