The success of these COVID-19 vaccines is remarkable and was far from guaranteed. mRNA is incredibly delicate. Enzymes in the environment and in our bodies are quick to chop mRNA into pieces ...

They found that the ribosome does more than just read the mRNA - it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists then ...

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators. The ...

They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

CMTM6 inhibits IGF2BP1 degradation in PDAC cells by reducing its polyubiquitylation. IGF2BP1 sustains the expression of EP300 and MYC mRNAs via m6A modification. This creates a positive feedback loop ...

However, mRNA itself is an exceptionally unstable molecule. This does not affect the safety of the therapy but limits its effectiveness—for example, by shortening the duration of action.

But even though these firsts took place during the pandemic, mRNA vaccines had been in development for many years before COVID-19 emerged as a threat. Looking forward, they'll likely continue to ...

we establish a differential model ‘m6ADyn’ encompassing mRNA transcription, methylation, export, and m6A-dependent and independent degradation. We validate the predictions of m6ADyn in the context of ...

m6A is a chemical modification found on mRNA molecules. It regulates various cellular processes, including mRNA stability and degradation, and plays a role in controlling protein synthesis. The role ...