They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

They found that the ribosome does more than just read the mRNA – it searches for m6A on the molecule and ensures that mRNAs with the modification are targeted for degradation. The scientists ...

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators.

But even though these firsts took place during the pandemic, mRNA vaccines had been in development for many years before COVID-19 emerged as a threat. Looking forward, they'll likely continue to ...

we establish a differential model ‘m6ADyn’ encompassing mRNA transcription, methylation, export, and m6A-dependent and independent degradation. We validate the predictions of m6ADyn in the context of ...

Messenger RNA (mRNA) acts as a blueprint for protein production, with certain chemical modifications like m6A acting as regulatory “comments” to control processes like degradation. Researchers at the ...

m6A is a chemical modification found on mRNA molecules. It regulates various cellular processes, including mRNA stability and degradation, and plays a role in controlling protein synthesis. The role ...

New Degradation Process for MRNA Discovered Researchers at the University of Würzburg (JMU) in Bavaria, Germany, have now focused on a specific modification, N6-methyladenosine (m6A).

The authors themselves highlight situations in which data do not support m6ADyn predictions. Active mechanisms to control m6A degradation levels or mRNA export levels could exist and may still play an ...

DDX5 promotes the modification of TLR2/4 mRNA with N6-methyladenosine, thereby triggering their degradation and reducing subsequent NF-κB-dependent inflammatory responses. DDX5 coordinates the ...