Customers looking for an mRNA therapeutic partner should prioritize operational excellence and choose flexible CDMOs.

Cancer metastasis, the spread of cancer to organs, is a major cause of cancer-related deaths. Once cancer spreads to multiple ...

For years, scientists worldwide have been experimenting with messenger RNA (mRNA) vaccines, unable to secure the funding or ...

Yet, naked mRNA is unstable, prone to degradation, and poorly absorbed by cells, limiting its effectiveness. This makes the development of reliable delivery methods essential for the future ...

Cancer metastasis, the spread of cancer to organs, is a major cause of cancer-related deaths. Once cancer spreads to multiple ...

This tail is the limiting step for mRNA degradation. “We wondered, why can’t we make multiple tails?” Wang said. “That way, if we lose one, there can be many others.” Wang and her team first ...

It is therefore no surprise that many cellular factors and mechanisms are devoted entirely to modulating the rate of mRNA degradation. Over the past five years, most of the enzymes involved in ...

National Institutes of Health officials have urged scientists to remove all references to mRNA vaccine technology from their grant applications, two researchers said, in a move that signaled the ...

Cancer metastasis, the spread of cancer to organs, is a major cause of cancer-related deaths. Once cancer spreads to multiple ...

Despite these structural features, mRNA molecules are relatively unstable compared to DNA. They have a shorter lifespan and are prone to degradation by cellular enzymes called ribonucleases (RNases).

These RNA molecules can interact with mRNA, influencing its stability, translation, or degradation, thus fine-tuning protein production in the cell. RNA interference (RNAi) is a cellular mechanism ...