Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

The derivative DOPE-C8, in particular, demonstrated the highest efficiency, enhancing endosomal escape and protecting mRNA from degradation in the bloodstream. It was also rapidly cleared from the ...

TRIM25 binds to and induces the rapid degradation of exogenous mRNAs, preventing their function. So how do the mRNA vaccines evade this cellular defense? A key finding of the study was that mRNA ...

"Its function: When m6A is attached to an mRNA, it triggers the degradation of the mRNA as soon as the first proteins have been produced according to the blueprint it contains. This is ...

Researchers have uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics, which could pave the way for more effective RNA-based therapies.

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise ...

Explore the impact of 3D models in drug discovery and how they enhance predictive insights in pre-clinical research.

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...