"Its function: When m6A is attached to an mRNA, it triggers the degradation of the mRNA as soon as the first proteins have been produced according to the blueprint it contains. This is ...

mRNA degradation is a crucial process in eukaryotic cells that regulates gene expression by controlling the lifespan of messenger RNA (mRNA) molecules. This regulation is essential for maintaining ...

An evolutionarily conserved mRNA-degradation pathway is initiated by the removal of the 3′ poly(A) tail. This disrupts the translation initiation complex and provides degradative enzymes with ...

The chemists developed the first active substance that inhibits the deadenylation of mRNA and thus prevents its degradation.

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers from the ...

Unlike short-read methods, long-read nanopore sequencing was effective for full-length and fragmented mRNAs, which provided insight into mRNA degradation. “Because you're sequencing the whole molecule ...

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers found that the neuronal energy conservation program determines the location and ...

During translation, ribosomes can pause on the nucleic acid. Researchers showed that collisions from incoming proteins get ...

Despite these structural features, mRNA molecules are relatively unstable compared to DNA. They have a shorter lifespan and are prone to degradation by cellular enzymes called ribonucleases (RNases).

m6A is a chemical modification found on mRNA molecules. It regulates various cellular processes, including mRNA stability and degradation, and plays a role in controlling protein synthesis. The role ...