"Its function: When m6A is attached to an mRNA, it triggers the degradation of the mRNA as soon as the first proteins have been produced according to the blueprint it contains. This is ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

This tail is the limiting step for mRNA degradation. “We wondered, why can’t we make multiple tails?” Wang said. “That way, if we lose one, there can be many others.” Wang and her team first ...

Bin Wu, associate professor in the department of Biophysics and Biophysical Chemistry at the School of Medicine, visited ...

Yet, naked mRNA is unstable, prone to degradation, and poorly absorbed by cells, limiting its effectiveness. This makes the development of reliable delivery methods essential for the future ...

A team of researchers led by Dr. KIM V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of ...

Despite these structural features, mRNA molecules are relatively unstable compared to DNA. They have a shorter lifespan and are prone to degradation by cellular enzymes called ribonucleases (RNases).

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise ...

A well-chosen delivery vehicle can also protect its mRNA cargo against degradation or immune recognition without the need for extensive chemical modification. “The field has moved forward ...

The derivative DOPE-C8, in particular, demonstrated the highest efficiency, enhancing endosomal escape and protecting mRNA from degradation in the bloodstream. It was also rapidly cleared from the ...

TRIM25 binds to and induces the rapid degradation of exogenous mRNAs, preventing their function. So how do the mRNA vaccines evade this cellular defense? A key finding of the study was that mRNA ...