A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big ...

Abstract: In one important chemical engineering unit operation of messenger ribonucleic acid (mRNA) vaccine manufacture, the precious mRNA payload is encapsulated in lipid nanoparticles. Recent ...

Details appeared recently in Nature Biomedical Engineering, in an article titled, “Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical ...

A study in the Journal of the American Chemical Society reports steps toward making inhalable mRNA medicines a possibility. Researchers outline their improved lipid-polymer nanoparticle for holding ...

Siloxane nanoparticles unlock precise organ targeting for mRNA therapy Changes to chemical structure allow for tissue-specific delivery Date: October 1, 2024 ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

AlphaFold 3 has a library of molecular structures. Researchers input a list of molecules they want to combine, then AlphaFold 3 uses a diffusion method to generate a 3D model of the new structure.