called base Z (2-aminoadenine), into mRNA to create Z-mRNA that has improved translational capacity, decreased cytotoxicity and drastically reduced immunogenicity compared to unmodified mRNA.

The pair's prize-winning and tenacious work on different types of RNA culminated in a 2005 breakthrough study showing that chemical modifications of mRNA bases (nucleosides)—adenine (A ...

Researchers have incorporated a base into mRNA that is not naturally present in the human body, producing mRNA that has decreased cytotoxicity compared to unmodified mRNA. Modified mRNA is more stable ...

To learn more, they created different variants of mRNA which had unique chemical alterations at their bases. They delivered these to dendritic cells and the results were huge. The inflammatory ...

Programmable mRNA antibiotics could be the solution to this problem. The strategy is simple: "We introduce short chains of bases into bacteria that are designed to exactly match specific genes ...

They found that mRNA-based COVID-19-vaccinations cause a significant and persistent change through acetylation, i.e., the binding of a chemical group to specific, immunologically relevant genes of ...

Beam Therapeutics Inc. (Nasdaq: BEAM), a biotechnology company developing precision genetic medicines through base editing, ...