Searches were performed with the following keywords: ‘tacrolimus population pharmacokinetics children’; ‘tacrolimus CYP3A5/pharmacogenetics children’ with the limit of ‘human’. All studies published ...

Using genetic markers to adjust initial doses of cyclosporine or tacrolimus may prove difficult, considering the variety of polymorphisms known to affect CYP3A4, CYP3A5, and MDR1. The current ...

Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China University of Chinese Academy of Sciences, Beijing 100049, China ...

Table 4 The association between SNPs of VIPDEGs and tacrolimus pharmacokinetics at the first month after LT. In this study, we found that SFTC increased the incidence of IR and dyslipidemia. Besides, ...

Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability ...