Is the indefinite self-renewal of adult cells possible without recourse to stem cell intermediates? Scientists have shown that it is possible, by achieving the ex vivo regeneration of macrophages ...

Role model stem cells: How immune cells can self-renew Date: January 21, 2016 Source: Max Delbrück Center for Molecular Medicine in the Helmholtz Association Summary: A research team has now ...

Stem cell renewal is limited - total number drops Until now it was thought that maintaining the stem cell pool was based on the self-renewal of individual stem cells.

OpenAI and Retro Biosciences used a custom AI model to redesign stem cell proteins, boosting efficiency and hinting at new ...

Balint Der et al, Cadherin adhesion complexes direct cell aggregation in the epithelial transition of Wnt-induced nephron progenitor cells, Development (2024). DOI: 10.1242/dev.202303 ...

To continuously grow precious stem cells in vitro, researchers must preserve their “stemness.” They often accomplish this by using feeder cells, such as mouse or human fibroblasts, that deliver ...

Specialized anatomical sites in the BM have been identified as stem cell niches, and these play essential roles in regulating the self-renewal and differentiation of HSCs through recently ...

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged ...

Embryonic stem cells (ESC) have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body. The embryonic stem cell state is established and ...

All cells in the body can acquire mutations, but without self-renewal, they cannot become the roots of cancer. Cumulative data suggest that precancer stem cells arise from clonally mutated tissue ...

The researchers happened upon DOT1L's role in stem cell self-renewal serendipitously. The gene is expressed widely; mice with a mutant version of DOT1L in all of their cells don't survive past the ...