Membrane proteins are key components of living cells. They constitute one-third of the ORFs of virtually all genomes, perform crucial roles, and are targeted by a huge number of drugs. When ...

Here we study how the tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by this sterol.

The quaternary protein structure refers to the orientation and arrangement of subunits in proteins with multi-subunits. This is only relevant for proteins with multiple polypeptide chains.

Where quaternary structure is not conserved among the members of a protein family, ... Levy, E. D. PiQSi: Protein quaternary structure investigation. Structure 15, 1364–1367 (2007) ...

Insulin protein structure is different among different species of animals. However, essentially it is a protein chain that is similar in many ways among animals.