Getting therapeutic drugs past the blood-brain barrier has long been one of medicine's most difficult challenges, limiting ...

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise ...

Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

New research reveals that the enzyme HDAC5 plays a critical role in suppressing a gene (Scn4b) that regulates brain activity associated with drug-related memories, which are central to relapse in ...

New research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b ... Together with our prior work, ...

Acetylation is a chemical modification that can be placed on and removed from the cable drum like a plug, causing changes in gene expression ... "Our findings show that mRNA vaccines induce ...

New preclinical data from a non-human primate (NHP) study show that a single, intravenous (IV) 1.3E13 vg/kg dose of Voyager's tau silencing gene therapy VY1706 resulted in dose-dependent knockdown of ...