Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

We aimed to define the impact of VD on oesophageal allergic inflammation. Design We assessed the genomic distribution and function of VD receptor (VDR) and STAT6 using histology, molecular imaging, ...

This was primarily due to increased expenses related to the investment in the STAT6 and TYK2 degrader programs, platform and discovery programs, as well as a rise in occupancy and related costs ...

For STAT6, we completed IND-enabling studies for ... The decision to expand the Phase II program was to structure the hidradenitis suppurativa and atopic dermatitis trials with the necessary ...

KT-621 (STAT6) Phase 1 healthy volunteer trial ongoing, complete SAD/MAD data expected in June 2025 KT-621 Phase 1b trial in atopic dermatitis (AD) patients expected to initiate in 2Q25 with data in ...

Credit: MPE “If you look at the distribution of the galaxy clusters in the sky in a spherical shell with a distance of 416 to 826 million light-years, you immediately notice a huge structure that ...

Anterior gradient 2 (AGR2) is a protein located in the endoplasmic reticulum involved in protein folding and when stressed, it is secreted into the extracellular space and it attracts monocytes, ...

Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family involved in the regulation of immune response and inflammation. The development of SH2 domain inhibitors ...

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Activation of an immune signaling molecule called STAT6 may lead to pulmonary hypertension (PH) in people with oxygen deprivation due to obstructive sleep apnea, according to a recent study in mice.

Solitary Fibrous Tumors (SFTs) are a rare malignancy defined by NAB2-STAT6 fusions. Because the molecular understanding of the disease is largely lacking, there are currently no targeted treatment ...