“As the first STAT6-targeted agent in clinical development, we believe KT-621 has the opportunity to dramatically alleviate the burden of disease for those suffering from AD by offering an effective ...

Considering our current knowledge that macrophage heterogeneity is more complex than M1/M2, an in vitro concept represented by ... via TRAF6-IKK-IRF5 signaling and efferocytosis via STAT6 mechanisms?

Macrophage polarization is regulated by various transcription factors, among which STAT6 is indispensable for M2 polarization. Stimulation of macrophages with IL-4 leads to IL-4R signaling and ...

Moreover, our results revealed that blockade of HDAC6 inhibited alternatively M2 macrophages polarization by suppressing the activation of TGF-β/Smad3, PI3K/AKT, and STAT3, STAT6 pathways. To give a ...

By contrast, depletion of STAT6 increased TNFα+ wound macrophages, made redox state more oxidized and ... macrophages exhibit plasticity as wounds repair and convert from M1 to M2 over the course of ...

Based on our preclinical observations, we believe exoASO-STAT6 is the first macrophage targeting candidate ... by exhibiting an immune suppressive M2 phenotype. Reprogramming TAMs toward a pro ...

The crosstalk between the M1 and M2 macrophage polarizing pathways, particularly the balance between activation of STAT1 and STAT3/STAT6, tightly regulates macrophage polarization and activity. A ...