News

EMBO Press1d
Snf1 and yeast GSK3-β activates Tda1 to suppress glucose starvation signaling
Tda1 protein kinase, activated by Snf1 and yeast GSK3-β, fine-tunes metabolism through the phosphorylation of Hxk2, which is implicated in yeast glucose repression. Tda1 is activated by both Snf1 and ...
Simultaneously targeting lysosomal enzyme and KRAS-MAPK pathway eradicates pancreatic tumors in preclinical models
Pancreatic cancer is a leading cause of cancer-related death, with a five-year survival rate of 13%. The high mortality is ...
Investing15d
US Q1 GDP Nowcast Continues to Ease, Signaling Stall-Speed Risk
The official first-quarter GDP report from the government that’s scheduled for Apr. 30 is expected to post a sharp slowdown in growth, based on the median estimate from several sources compiled ...
Forex Factory15d
China consumer prices drop 0.1% in March signaling rising deflationary pressures
Consumer prices in China slid 0.1% year on year in March, remaining in deflationary territory after having contracted 0.7% in February. Economists polled by Reuters had expected a flat reading ...
Frontiers16d
Orthoflavivirus infection and the mTOR signaling pathway
In this work, the mechanism underlying the relationship between the mTOR signaling pathway and orthoflavivirus infection was ... and activation of S6K by pyruvate dehydrogenase kinase 1, thereby ...
Wall Street Journal18d
How Markets Solved the GLP-1 Shortage
Cox/Getty Images/Adam Gray/Bloomberg News/Billy Tompkins/Zuma Press Policymakers could learn a thing or two about the value of competition in healthcare from the recent shortage of GLP-1 drugs ...
World Scientific18d
Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Department of General Surgery, Tianjin Union Medical Center, Tianjin 300122, P. R. China These authors contributed equally to this work.
C&EN20d
Persistent Directed Flag Laplacian (PDFL)-Based Machine Learning for Protein–Ligand Binding Affinity Prediction
Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States ...
The EMBO Journal21d
CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis
CD47-amyloid-β-CD74 signaling is a key driver of adaptive immunosuppression in sepsis, suppressing B cells and impairing immunity. Blocking this pathway restores immune ... including Pax5 and CD19, ...
NPR24d
White House says it's 'case closed' on the Signal group chat review
The White House has concluded its review of how Atlantic editor Jeffrey Goldberg was inadvertently included on a Signal message group chat of high-ranking officials discussing impending strikes in ...
The New York Times25d
Trump Administration Highlights: President Says He’s ‘Not Joking’ About a Possible Third Term
Let me first hand out two $1 million checks in appreciation ... Jeffrey Goldberg of The Atlantic, through a Signal chat should be classified. He added that the White House claim that no classified ...