Organoids were cultured from healthy donor iPSC sources and differentiated using the human iPSC-derived Cerebral Organoid ...

USH2A mutations are one of the most common causes of non-syndromic RP. In this study, we developed retinal organoids (ROs) and retinal pigment epithelium (RPE) cells from induced pluripotent stem ...

Aim To develop a deep learning (DL) model that predicts age from fundus images (retinal age) and to investigate the association between retinal age gap (retinal age predicted by DL model minus ...

Researchers have identified novel retinal vascular signatures that are significantly associated with the risk for a first stroke. When combined with age and sex, these retinal “fingerprints ...

In their last study, IIT's research group saw for the first time that Ziapin2 also acts in a similar manner on neurons in the inner retina unaffected by degeneration, particularly at the bipolar ...

Certain retinal organoids derived from iPSCs have the advantage of emulating the native tissue more closely. They contain nearly all major types of cells in the native retina, including photoreceptors ...

Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk.

Derived from healthy donor iPSCs, its RPE cells uniquely have the same genetic background as retinal organoids, enabling parallel examination of RPE and neurosensory retina. Newcells can also ...

Design A large human gastric IM organoid (IMO) cohort (n=28), their clonal derivatives and normal gastric organoids (n=42) for comparison were established. Comprehensive multi-omics profiling and ...

Tests in human retinal organoids and primate retinas showed increased levels of protocadherin-15 in light-sensing cells, offering hope for vision preservation.