Bind remains in rotation, retaining its position as a fan-favorite ... The ranked reset at Act 3’s launch incorporates a Rank Shield system, preventing demotions between major tiers (e.g., Platinum 1 ...

US President Donald Trump's tariffs will likely push up prices and constrain growth, and could put the Federal Reserve in the unenviable position of having to choose between tackling inflation and ...

Results and Discussion: It is found that out of the 5 drugs, Ritonavir and Paritaprevir bind to the NS2B-NS3 protease of the ZIKV strongly with the Gibbs binding free energies (∆G bind) of −17.44±3.18 ...

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States Department of Computational Mathematics, Science and Engineering, Michigan ...

These are useful, e.g., to compare drugs with different scaffolds. In this study, we approach the calculation of ABFE from a different angle. Instead of concentrating on a single protein that binds ...

G-FY and G-FH conceived of the research plan. J-FY, C-YY, and DW performed the project. G-FY, G-FH, J-FY, and C-YJ wrote the manuscript. This work was supported in part by the National Key R&D Program ...