In a study published today in the journal Nature, Bloom and his colleagues describe how they used this method – called pseudovirus-based deep mutational scanning – to identify recent mutations to the ...

They then sicced this “pseudovirus” on some cells, to see how it measured up to previous generations of COVID. The results, while not yet peer-reviewed, are promising. This new kind of COVID ...

Notably, the DMS platform could also measure change in IC50 values (a measure of the potency of antibody neutralization) caused by escape mutations, which correlated well with the IC50 measured by ...

A new study posted to the preprint server bioRxiv* describes a pseudovirus system based on deep mutational scanning (DMS) to demonstrate how known and future mutations could affect the ability of ...

Do a person’s antibodies work to block the COVID-19 virus from infecting one’s system? Are these antibodies also capable of blocking emerging variants such as the omicrons? These are the ...

He added, “This platform will allow us to investigate the immunogenicity of pseudovirus nanoparticles (PVNPs) displaying various antigenic combinations and assess the potential effectiveness of ...

Pseudovirus and authentic virus testing demonstrate that bebtelovimab retains full neutralizing activity against Omicron – currently the predominant variant in the U.S. In addition, pseudovirus ...

3 The neutralization titers against the D614G variant that were measured in the pseudovirus assay used in our study were a correlate of vaccine efficacy in the COVE trial. 4 We found that the ...

The Omicron pseudovirus infected cells at a higher rate than other pseudovirus variants. The results demonstrated a booster dose of an mRNA COVID-19 vaccine provided the best immune protection ...

A shortcut is to produce a "pseudovirus" - a harmless chassis borrowed from another virus that then has the genes from Omicron copied and pasted into it. This is the approach vaccine companies ...