A new method has been developed that can change the behaviour of certain cells in the body, transforming them from helping cancer grow to fighting it. Normally, there are cells in our bodies that ...

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom. William Harvey Research Institute, Barts and The London ...

1University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado. 3Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.

Our data show that PAC-1 modulates sunitinib-induced autophagy and blocks lysosomal trapping, potentiating sunitinib activity and increasing death of cancer cells. As both drugs are well-tolerated in ...

29Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom. 32Haematology and Oncology Department, Great Ormond Street Hospital, London, United Kingdom.

Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division. Spindle tethering factors such as ...

Therefore, interactions between vascular endothelial cells, neurons, and glial cells are critical for the understanding of HD. However, in vivo animal models are often limited by the complexity of ...

We differentiated induced pluripotent stem cells from risk, nonrisk donors at 9p21.3, and isogenic knockouts into vascular smooth muscle cells (VSMCs). We performed single-cell transcriptomic ...