mRNA splicing is a fundamental part of the process ... might be treated by repositioning the normal copy of the gene for that ...

"Incorrect splicing of REST mRNA can cause the resulting protein to ... allowing it to splice into its normal form. The researchers implanted neuroendocrine cancer cells under the skin of lab ...

RT-PCR and sequencing revealed a small amount of normal-size mRNA with normal exon 1-exon 2 splicing. Quantitative RT-PCR on mutant LMSF showed AR mRNA levels were well below 10% of normal ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA splicing. Two molecular control factors play a key role in splicing, the process ...

6 The process of pre-mRNA splicing removes introns and stitches ... miRNAs are central to many normal developmental pathways, having been implicated in the development of most organs and cells.

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

Splicing does more than it was initially cut ... During translation of normal mRNA, Y14 (located upstream of exon–exon junctions) would be removed. As the termination codon of higher eukaryotes ...

The introns need to be cut out of the pre-mRNA in the cell nucleus and the exons reconnected at the interfaces. This process is known as splicing. Ultimately, the spliced messenger RNA consists of ...

The role of gut microbiome and inflammation in endometriosis. Endometriosis, which causes pain in the pelvis and lower abdomen and can lead to infertility, afflicts 1 in 10 women in reproductive age.