The analysis pinpointed collagen alpha-1 fragments, a fundamental protein form in bone. Further confirmation came from the Center for Proteome Research at the University of Liverpool and UCLA, where ...

Key Findings: NGPS provided single amino acid resolution for IL-6 peptide fragments critical to receptor binding and function, resolving regions with low sequence coverage by mass spectrometry.

Native Mass Spectrometry (nMS) is a versatile technique for elucidating protein structure. Surface-Induced Dissociation (SID) is an activation method in tandem MS predominantly employed for ...

Discover effective methods to determine the gravimetric sample composition of mixtures with unknown constituents, ensuring reliable analytical results.

Native mass spectrometry analysis of proteins directly from tissues can be performed by using nanospray-desorption electrospray ionization (nano-DESI). Typically, supplementary collisional activation ...

An example is seen in Figure 4 for the nanoscale secondary ion mass spectrometer (NanoSIMS), 7 which has 6 movable and 1 fixed EM detectors, permitting simultaneous analysis of 7 different masses.

These limitations can lead to inaccurate mass assignments preventing the characterization of large heterogeneous proteins or complexes, such as highly glycosylated proteins, aggregates, and genome ...

At the heart of any mass spectrometer is the mass analyzer. This component takes the ionized masses and separates them based on their mass-to-charge ratio (m/z). In this article, we consider some of ...

Results are presented for femtosecond (fs) laser desorption postionization mass spectrometry (LDPI-MS) using 7.9 eV single photon ionization for the detection of drug compounds that have previously ...

Historical Commentary Published: 28 July 2011 A century of mass spectrometry: from atoms to proteomes John R Yates III Nature Methods 8, 633–637 (2011) Cite this article ...

Physicists Create First Nanoscale Mass Spectrometer Date: July 24, 2009 Source: California Institute of Technology Summary: Using devices millionths of a meter in size, physicists have developed a ...