Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer. “When we use embryonic stem cells, they ...

Several lines of evidence suggest this pathway regulates mammary stem cell dynamics in normal mammary epithelial homeostasis. We are particularly interested in how alternative “noncanonical” modes of ...

and Li, Y. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene 24, 4220-4231 (2005). PMID: 15824740. Li, Y. and Rosen, ...

Where the research has really made a difference is with stem cells. Because Dolly came from an adult sheep’s mammary cell, scientists learned they could change a cell’s gene expression when ...

and human mammary epithelial cell lines for the study of breast cancer, three dimensional culture, and carcinogen screening. Its human cell culture products also consists of adult stem cells and ...

It's no secret that our waistlines often expand in middle-age, but the problem isn't strictly cosmetic. Belly fat accelerates aging and slows down metabolism, increasing our risk for developing ...

She was born in 1996 after scientists figured out how to remove the DNA from the egg cell of a Scottish Blackface sheep and basically replace it with the DNA of a mammary cell from a Finn Dorset ...

we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, and the hematopoietic system. Pekka is a ...

The cancer contains pluripotent cancer stem cells, which have the ability to ... and couldn't be detected if a mouse had a mammary tumor instead of a malignant testicular cancer, or if a ...

We have established variety of three-dimensional culture systems for mammary primary and stem cell-based organoids as well as patient tumor-derived explants for ex vivo target validation and for ...