A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional ...

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and ...

Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail the growth of several cancer types. A review paper published last year in European ...

What additional lessons can be learned? Is MYC stability altered at specific subcellular locales, or when in partnership with certain DNA, RNA or protein molecules, or as a mechanism to regulate ...

University of Pennsylvania researchers have developed a powerful new investigative tool to reveal how proteins work inside ...

This protein can work together with mutant Myc to drive cancer, so the inflammasome's normal job of keeping Ras in check ...

At the same time, the lab is now applying the methodology developed here to the degradation of key proteins involved in cancer, including c-Myc and K-Ras. "This is just the beginning," says Schultz.

UTR Therapeutics Inc. has submitted an IND application to the FDA for UTRxM1-18, a novel therapeutic approach for targeting c-MYC-driven cancers. Pending approval, a first-in-human phase I trial is ...

The mitochondrial unfolded protein response (UPR mt ... They also identified c-Myc as a key factor in the activation of UPR mt —overexpression of c-Myc significantly increased the expression ...

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer ...