P enn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the ...

A key challenge remains finding a delivery system that enables enough of the mRNA to reach target tissues safely without causing adverse effects. Lipid nanoparticles have been studied since the ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the mRNA ...

such as direct injection of naked mRNA, lipid-based carriers, polymers, and protein derivatives. Those COVID vaccines that have experienced success are based around lipid nanoparticle delivery.

Following encapsulation in two specifically designed Lipid Nanoparticles, the resulting K1.1c-mRNA-LNP and K1.1d-mRNA-LNP were efficiently delivered to orthotopic engrafted HCC tumors in mice in a ...

the precious mRNA payload is encapsulated in lipid nanoparticles. Recent elegant cryogenic-transmission electron microscopy [Biophys J 120, 2766 (2021)] reveals that these lipid nanoparticles take the ...

This new lipid nanoparticle production system developed by Shin-Etsu Chemical and Hokkaido University is capable of small-batch and mass production ...