the RNA technology company eTheRNA explored the possibility of encapsulating the mRNA in lipid-based nanoparticles (LNPs). To find the best formulation of LNP to bring mRNA into cells, the company ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

As we previously discussed, beginning in 2022, a series of patent infringement lawsuits were filed against Moderna and collaborators ...

Lipid nanoparticle (LNP) mRNA vaccines emerged during the COVID-19 pandemic to form an almost miraculous protection against a virus, which killed millions around the world. Aided by expedited ...

“The lipid nanoparticles have evolved to significantly ... infectious pathogens or treat cancer and autoimmune disease. mRNA LNP would allow the body to produce the antibodies directly, thus ...

Following encapsulation in two specifically designed Lipid Nanoparticles, the resulting K1.1c-mRNA-LNP and K1.1d-mRNA-LNP were efficiently delivered to orthotopic engrafted HCC tumors in mice in a ...

Following encapsulation in two specifically designed Lipid Nanoparticles, the resulting K1.1c-mRNA-LNP and K1.1d-mRNA-LNP were efficiently delivered to orthotopic engrafted HCC tumors in mice in a ...

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the mRNA ...

Their findings are published in Cell Reports Medicine in the paper "Modulation of lipid nanoparticle ... compared to mRNA and protein-in-adjuvant formulations. The DNA-LNP induced a unique ...