Replacing PEG with PCB in lipid nanoparticles led to potent mRNA vaccines that avoided unwanted immune responses.

a pioneering technology provider specializing in mRNA and lipid nanoparticle (LNP) technologies. This collaboration seeks to revolutionize the discovery and development of therapeutic antibodies b ...

Modification of PEG length and content will impact biomolecular corona adsorption, in which influence the LNP therapeutic efficiency. Besides PEGlation, the conjugation of ligands or antibody on ...

The LNP-mRNA modality is a novel approach that ... Immunogenicity testing focuses on detecting small amounts of antidrug antibodies, so assay sensitivity needs to be carefully determined.

Key experiments using an influenza DNA-LNP vaccine model demonstrated robust antibody and T cell immunity, lasting over a year in animal models. Additionally, a single shot of SARS-CoV-2 spike DNA ...

Innovative delivery techniques, including high-tech nanoparticles and electroporationdevices, may convey more gene therapies into the clinic.

Designed to empower researchers, the Aplo Scope provides real-time insights into complex biological systems, enabling breakthroughs in drug delivery, biomarker discovery, and antibody therapeutics ...

In contrast, polyethylene glycol (PEG)-lipid standards, commonly used in current LNP formulations, elicited a strong and boosted antibody response. Anti-PEG antibodies have been implicated as a ...