Replacing PEG with PCB in lipid nanoparticles led to potent mRNA vaccines that avoided unwanted immune responses.

Modification of PEG length and content will impact biomolecular corona adsorption, in which influence the LNP therapeutic efficiency. Besides PEGlation, the conjugation of ligands or antibody on ...

The surface of the LNP may be coated with targeting proteins, such as antibodies or their fragments, to ensure the payload is delivered to the correct cell type. A common way to produce LNPs ...

The LNP-mRNA modality is a novel approach that ... Immunogenicity testing focuses on detecting small amounts of antidrug antibodies, so assay sensitivity needs to be carefully determined.

a pioneering technology provider specializing in mRNA and lipid nanoparticle (LNP) technologies. This collaboration seeks to revolutionize the discovery and development of therapeutic antibodies b ...

where they observed strong T cell and antibody responses that persisted into the memory phase. Finally, the team examined whether DNA-LNP vaccines could be protective in a live SARS-CoV-2 ...

Designed to empower researchers, the Aplo Scope provides real-time insights into complex biological systems, enabling breakthroughs in drug delivery, biomarker discovery, and antibody therapeutics ...