No good deed goes unpunished in Urchin, a London-set character study that shows so much sophisticated and worldly wisdom it’s ...

In recent years, scientists have made big strides in understanding mental health conditions like autism spectrum disorder (ASD), schizophrenia, and Alzheimer’s disease. They’ve found certain genetic ...

Axon guidance cues direct nerves in the heart during development, disease and regeneration. These cues determine cardiac innervation patterning by regulating the balance between chemo-attraction and ...

Researchers described the SIK3-N783Y mutation in a new study after testing it on sleep-deprived inbred mice.

TM6SF2 GKO mice fed an HFD showed elevated liver and intestinal lipid deposition compared to CON mice. The gut microbiota of HFD-fed TM6SF2 GKO mice exhibited a decreased Firmicutes/Bacteroidetes ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

JONATHAN LAMBERT, BYLINE: Neuroscientist Li Zhang has anesthetized a lot of mice for his research. Several years ago, as he brought these knocked-out mice back to their cages, he started noticing ...

Li and his colleagues took a different approach. The team used gene editing to knock out imprinted genes altogether. Around 200 of a mouse’s genes are imprinted, but Li’s team focused on 20 ...

Collaborating with study co-authors Zachi Horn, a former postdoc in the Hatten lab, and with assistance from Shiaoching Gong, of Weill Cornell Medicine, Hanzel spent two years creating a knockout ...

2009). Heterozygous KO mice were intercrossed to generate homozygous KO mice (Parisiadou et al., 2009). This knock-out (KO) model was generated by deleting exon 2 of the Lrrk2 gene, which results in a ...