A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.

ATX-559, a first-in-class oral DHX9 inhibitor, is being evaluated in a Phase 1/2 study with a focuson advanced or metastatic ...

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of ...

By binding uniquely to the helicase domain of WRN, IDE275 (GSK959) delivers potent and selective inhibition across MSI-H models," said Michael White, Ph.D., Chief Scientific Officer, IDEAYA ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature's DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

“Our study highlights WRN as a contributor to the integrity of CH and points at the altered levels and distribution of LBR as a mediating mechanism.” “Our study highlights WRN as a ...

WRN is a helicase required for DNA replication and DNA repair and is a validated target for tumors with microsatellite instability (MSI). Nimbus will present preclinical data on NTX-452 ...

In parallel, MOMA announced the selection of a development candidate for its second lead program, MOMA-341, an oral potent and selective covalent Werner helicase inhibitor for treatment of cancers ...

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. RNA-binding proteins are identified as regulators of cardiac disease; DDX5 (dead-box helicase 5) is a master regulator of ...

Ubiquitylation-dependent CMG helicase disassembly is the final step during DNA replication in eukaryotes. This study identifies a second pathway for replisome disassembly in budding yeast cells, which ...

Different RNA helicases, particularly those in the dead box helicase (DDX) family, are dysregulated in cancer; however, there have been very few attempts to produce small molecule inhibitors.

Helicase inhibitors, however, are hard to come by. By testing thousands of small molecules, drug companies have occasionally happened upon methods for grinding one helicase or another to a halt ...