Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

are likely to modulate the ratio of active to inactive G proteins rather than the time course of activation, and that the distribution of activated G proteins probably reflects the shallow ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches ...

Cell-based assays are the predominant means of assessing GPCR activation, but are limited by their inherent complexity. Functional molecular assays that directly and specifically report G protein ...

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Scientists discovered a hidden CB₁ receptor pocket and engineered a drug to exploit it, offering promise of safer, more ...