are likely to modulate the ratio of active to inactive G proteins rather than the time course of activation, and that the distribution of activated G proteins probably reflects the shallow ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches ...

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes ...

Cell-based assays are the predominant means of assessing GPCR activation, but are limited by their inherent complexity. Functional molecular assays that directly and specifically report G protein ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Scientists discovered a hidden CB₁ receptor pocket and engineered a drug to exploit it, offering promise of safer, more ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...