Bacterial species study challenges assumption that structural similarity predicts protein behavior
A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...
EurekAlert!1d
New study uncovers key differences in allosteric regulation of cAMP receptor proteins in bacteria
A new study led by Dr. Rodrigo Maillard at Georgetown University, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology,” published in ...
Le Lézard1mon
RiDYMO® Designs Cyclic Peptide for "Undruggable" ?-Catenin Target Within Two Months
BEIJING, Jan. 8, 2025 /PRNewswire/ -- In a recent achievement, DP Technology's hit discovery platform RiDYMO® has successfully designed a cyclic peptide targeting ?-catenin, a historically ...
Morningstar1mon
RiDYMO® Designs Cyclic Peptide for "Undruggable" β-Catenin Target Within Two Months
BEIJING, Jan. 8, 2025 /PRNewswire/ -- In a recent achievement, DP Technology's hit discovery platform RiDYMO® has successfully designed a cyclic peptide ... Wnt/β-catenin signaling pathway.
Thailand Business News1mon
RiDYMO® Designs Cyclic Peptide for "Undruggable" β-Catenin Target Within Two Months
One standout compound, designated as compound 24, effectively bound to β-catenin, disrupted its interaction with BCL9, and inhibited the Wnt/β-catenin signaling pathway. Fig. 3 Experimental Results of ...
Frontiers1mon
Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity
our investigation of the molecular mechanism of abnormal decidualization of endometrial stromal cells in adenomyosis primarily reveals abnormalities in pathways such as phosphatidylinositol ...