Research on gastrointestinal diseases, especially cancer, has mainly focused on epithelial cells ... Considerations for Single-cell Transcriptomic Profiling of Human Colon Biopsies, Cellular ...

Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes ...

CytomX's CX-2051, a PROBODY® EpCAM-targeted antibody-drug conjugate (ADC), showed a 28% confirmed response rate and 5.8-month ...

Moreover, a step-wise colorectal carcinogenesis model has been proposed wherein normal epithelial cells transition to adenoma (non-cancerous tumor) and then to carcinoma (cancerous tumor ...

A first-in-human clinical trial tests a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers.

These models include humanized stem cell-derived in vitro systems that recreate the epithelial cell layer makeup and morphology. 2 Towards this end, scientists increasingly employ monolayer systems.

Calcitriol maintains intestinal epithelial cell differentiation and integrity, which is crucial for preventing colorectal cancer (CRC). Moreover, calcitriol triggers G1 cell cycle arrest ...