In light of this, our laboratories have undertaken studies of cardiac chromatin organization in the context of cardiovascular disease. 1,2 The approach to this question involved using HiC technology ...

Intel Foundry Direct Connect highlighted how the Santa Clara, California-based chipmaker sees this advanced packaging technology in its future roadmaps. More technical details about EMIB-T are likely ...

This will help develop a better understanding of the ways in which chromatin packaging shape gene expression and, ultimately, lifespan in C. elegans. The research is funded by a grant from the ...

These chromatin packing domains are critical for regulating gene expression, DNA replication and preventing DNA damage. While it's well known that DNA processes are disrupted in cancer, ...

Cryo-electron tomography allows the investigation of nucleosome-level chromatin structure and to test different chromatin compaction models. This study improves sample preparation, revealing ...

The building blocks of this genetic packaging material are called nucleosomes, which comprise sections of DNA that are wound around a core of proteins called histones, resembling beads on a string.

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

The re-expression of fetal cardiac genes during disease requires coordinated chromatin remodeling. Local chromatin packing around the nucleosome protein complex is understood with atomic resolution; ...

We present herein a minimal model based purely on molecular, physical, and statistical principles which (1) preserves the efficiency of chromatin packing, (2) produces the structural heterogeneity and ...

As we show below, chromatin packing domain organization will be weakly and inversely related to the probability of return events but strongly associated with the local volume concentrations. Figure 5.

We hypothesized that chromatin architecture plays a role in regulating transcriptional heterogeneity in ovarian cancer stem cells (OCSCs) to maintain stemness and chemoresistance. PWS microscopy ...