This thesis investigates how human cells carry out the critical task of packaging copied DNA. We developed human cells in which this process can be quickly turned off, allowing us to study the ...

Four years before Kimberly Gallagher enrolled in Medicaid herself, the public health insurance program's rules prompted her ...

Chromatin remodelling is the process by which the DNA wrapped within nucleosomes becomes accessible to regulatory elements, such as transcription factors and the replication machinery.

Chromatin structure is thought to regulate transcription factor access by modulating DNA accessibility. Here, the authors show that in living human cells, euchromatin and heterochromatin are fully ...