Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Studies presented at the ASCO Annual Meeting 2025 highlighted immunotherapies that may provide new standards of care for certain cancers as well as immunotherapies that are breaking new ground by ...

This valuable study identifies asymmetric dimethylarginine (ADMA) histones as potential determinants of the initial genomic binding of Rhino, a Drosophila-specific chromatin protein essential for ...

We have developed a streamlined proteomic sample preparation protocol termed Accelerated Barocycler Lysis and Extraction (ABLE) that substantially reduces the time and cost of tissue sample processing ...

If Stephen Quake gets his way, biologists in the future will spend a lot less time wielding pipettes. “Our goal,” he says, ...

Activated T cells form an immunological synapse with tumor cells, resulting in tumor cell lysis and the release of cytokines (e.g., IFN-γ, TNF-α, IL-2, IL-10), which boost T cell proliferation and ...

Protocol 7. Bacterial Re-Streaking Techniques Protocol 8. Lysis of E. coli Cells with Lysozyme Protocol 9. Polymerase Chain Reaction (PCR) Protocol 10. Inverse PCR Mutagenesis Protocol 11. Colony PCR ...