EurekAlert!15d
JMC | Insilico Medicine unveils novel AI-driven FGFR2/3 inhibitor to overcome resistance tumor mutations
Insilico Medicine (“Insilico”) announces that the team, with the support of its generative chemistry engine, has developed a novel and highly selective FGFR2/3 dual inhibitor, which maintains efficacy ...
SciELO20d
Synthesis and Biological Activity of Trolox Amide Derivatives
The most common method for creating an amide bond is the use of carbodiimide condensing agents such as dicyclohexylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride. The ...
C&EN22d
Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 Inhibitors that Overcome Mutant Resistance
Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China ...
C&EN23d
Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic Warhead
Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China ...
Frontiers1y
Metagenomic and metaproteomic analyses of microbial amino acid metabolism during Cantonese soy sauce fermentation
Soy sauce were obtained from Guangdong Meiweixian Flavouring Foods Co., Ltd. Three fermenters were randomly selected from 100 fermenters (Zhongshan, China), and three biological repeats were made for ...
Frontiers3y
Metformin-Inducible Small Heterodimer Partner Interacting Leucine Zipper Protein Ameliorates Intestinal Inflammation
Small heterodimer partner interacting leucine zipper protein (SMILE) is an orphan nuclear receptor and a member of the bZIP family of proteins. We investigated the mechanism by which SMILE suppressed ...