Overall survival (OS) in BRCA -mutated breast cancer improved significantly with the addition of olaparib (Lynparza) to ...

Triple-negative breast cancers are often characterized by defects in DNA repair mechanisms involving ... type 1 susceptibility protein (BRCA1). Indeed, mutations in BRCA1 are known to predispose ...

Mutations in BRCA2 — a gene known to repair damaged ... Grossman School of Medicine unveils a previously unknown protective mechanism employed by the gene — and how an existing class of ...

Now, let’s hope I don’t get hit by a bus.” Applegate has the BRCA1 gene mutation, which predisposes her to developing cancer. A major concern is that her 6-year-old daughter Sadie could have ...

It is recommended that prophylactic surgery should be performed as soon as possible, simply because of the early development of cancer in BRCA mutation carriers. Although ovarian cancer rarely ...

Mutations in BRCA2—a gene known to repair damaged DNA ... Grossman School of Medicine unveils a previously unknown protective mechanism employed by the gene—and how an existing class of ...