Ovarian cancer (OC) is the fifth most common cause of cancer-related mortality worldwide and represents the leading cause of death for gynecological malignancies. Nevertheless, over the last years, ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a ...

Triple negative breast cancer accounts for 15% of cases but causes a disproportionate number of deaths. Learn about symptoms ...

Therapeutics announced the presentation of new clinical data from its ongoing Phase 2 trial with stenoparib monotherapy in ...

Adding immunotherapy to new KRAS inhibitors boosted responses in preclinical models, setting the stage for future trials of the combination strategy.

Adding immunotherapy to a new type of inhibitor that targets multiple forms of the cancer-causing gene mutation KRAS kept ...

Learn how BRCA gene mutations impact family planning and fertility. Understand risks, options, and expert advice for safe pregnancies despite cancer concerns.

Among patients with early-stage triple-negative breast cancer, a beneficial pathologic complete response rate was higher in patients with BRCA1/2 mutations. Among patients with early-stage ...

Mutations in BRCA1 and BRCA2—tumor suppressor genes that play a crucial ... “This highlights a distinct mechanism of cytotoxicity, where excessive resection, rather than failed DNA repair by ...

Cells normally use highly accurate mechanisms to fix these breaks, but some cancers -- particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ovarian cancers -- lack ...

Cells normally use highly accurate mechanisms to fix these breaks, but some cancers-particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ovarian cancers-lack this ...

1Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas. 2Department of Biochemistry, The University of Texas Southwestern Medical Center at ...