A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...

Researchers at MUSC Hollings Cancer Center have identified a signaling loop involved in the growth and persistence of ...

A protein called BMPER found at low levels in models has emerged as a PAH treatment target as it may ease disease progression ...

All diseases exist on a continuum, and the damage often begins early—sometimes as soon as a child is weaned off breast milk and starts consuming regular table food. In a previous blog, I discussed ...

The ion channel PIEZO2 doesn't just convey touch stimuli. It also plays a key role in the development of coronary vessels, a team led by Annette Hammes from the Max Delbrück Center reports in Nature ...

Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC ...

Endothelial cell dysfunction, in its broadest sense, encompasses a constellation of various nonadaptive alterations in functional phenotype, which have important implications for the regulation of ...

The endothelial cells of the blood circulation are exposed to hemodynamic forces, such as cyclic strain, hydrostatic forces, and shear stress caused by the blood fluid’s frictional force. Endothelial ...

In response to extracellular vasoactive stimuli, endothelial cells can release several diffusible signaling substances, such as nitric oxide, which is a vasodilator (2). Endothelial cells also ...

1 Introduction Vascular endothelial cells (ECs) constitute the inner cellular lining of all blood vessels, including arteries, veins and capillaries, and are therefore essential for maintaining life.