In neonatal mammals, arginine is synthesized in the enterocyte, with either proline or glutamate as the dietary precursor. We have shown several times in piglets that proline is the only precursor ...

In this study, doxazosin titration occurred on a monthly basis. Secondary outcomes included all-cause mortality, stroke, and all major cardiovascular disease events. If patients did not meet the ...

Objectives To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss. Methods L-arginine was applied to three arthritis models (collagen-induced arthritis ...

Institute for General Microbiology, Christian Albrechts University, Kiel, Germany Center for Synthetic Microbiology (SYNMIKRO) Research Center and Department of Chemistry, Philipps-Universität Marburg ...

Biophysical studies of a 21-residue phosphorylated PRLR fragment using isothermal titration calorimetry (ITC) and NMR spectroscopy show an interaction with a kinetic phase on the minute time scale. In ...

Intranasal vaccination is a desired route for protection against influenza viruses by mucosal and systemic immunity. However, the nasal mucosa impedes the intranasal delivery of vaccines. Here, we ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Algorithms that constrain metabolic network ...

Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant for treating psychiatric disorders. Associations are strong enough to feature on drug labels and for ...

Development and optimization of the cap-iELISA A checkerboard titration method was utilized to determine the optimal concentration of the coated antigen and the proper serum dilution (20), Both ...

Objective Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The ...