Researchers have identified a promising strategy to improve memory and brain cell function in models of 22q11.2 Deletion ...

When Columbia neurologist and scientist Neil Shneider speaks to his ALS patients who volunteer for experimental therapies, he's unwaveringly honest. "Patients always ask me, 'What can I hope to get ...

A new study shows that lowering MSH3, a key DNA repair protein, with antisense oligonucleotide (ASO) therapy can stop CAG repeat expansions in HD patient-derived brain cells. This could be a promising ...

U of A professor of medical genetics Toshifumi Yokota and the Yokota Lab are making advancements in gene therapy.

HT-KIT is engineered to selectively bind to mutant KIT mRNA transcripts and block their translation, thereby preventing the production of the KIT protein, a critical driver of tumor growth in cancers ...

The bases remain similar to those in DNA, allowing PNAs to target transcripts. As antisense molecules, PNAs bind to complementary messenger RNA (mRNA), blocking its function and inhibiting the ...

Japan's Ono Pharmaceutical bought an antisense oligonucleotide from Ionis ... import ban As China bans Illumina’s importation of DNA sequencers in retaliation to new U.S. tariffs, the company ...

Idaho investigators found a three-person mixture of DNA under the 21-year-old University of Idaho undergrad's fingernails after she and three friends were killed in her off-campus rental home in ...

Less than a month after researchers unveiled that a “ticking DNA clock” is behind Huntington’s disease (HD), scientists have now identified an antisense oligonucleotide (ASO) that can slow ...

In this study, the team worked to determine the quality antisense ONs (ASOs) attributes ... ONs are short single- or double-stranded DNA or RNA molecules used to modulate gene and protein expression, ...

First explained in 1978, antisense oligonucleotides are short, single-stranded synthetic fragments of DNA or RNA that bind specifically to the target RNA sequence inside cells and modulate protein ...